SPRUCE BIOSCIENCES INC (SPRB) Institutional Shareholders
SPRUCE BIOSCIENCES INC (SPRB) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $108.16M in SPRB holdings during the latest filing period.
Aigh Capital Management Llc is currently the largest disclosed institutional shareholder of SPRB tracked by InsiderSet, reporting ownership valued at approximately $13.50M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $13.26M, representing an estimated loss of -1.76% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 66% of the total disclosed SPRB value among the investors covered in this analysis. Major shareholders include Aigh Capital Management Llc, Orbimed Advisors Llc, Blackrock, Inc., and several other long-term asset managers with concentrated positions in SPRUCE BIOSCIENCES INC (SPRB).
This page ranks the largest institutional SPRB shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
64
Total Reported Value
$108.16M
Largest Holder
Aigh Capital Management Llc
Largest Position
$13.50M
Insider Transactions (90d)
2
Latest Filing Quarter
Q2 2026
New Institutional Positions
73
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Aigh Capital Management Llc | 1.22% | 250,000 | $13,500,000 | $13,262,500 | -$237,500 | -1.76% | |
| Orbimed Advisors Llc | 0.20% | 200,000 | $10,800,000 | $10,610,000 | -$190,000 | -1.76% | |
| Blackrock, Inc. | 0.00% | 187,836 | $10,143,144 | $9,964,700 | -$178,444 | -1.76% | |
| Millennium Management Llc | 0.01% | 160,981 | $8,692,974 | $8,540,042 | -$152,932 | -1.76% | |
| Ikarian Capital, Llc | 1.07% | 121,356 | $6,553,224 | $6,437,936 | -$115,288 | -1.76% | |
| Vanguard Capital Management Llc | 0.00% | 119,331 | $6,443,874 | $6,330,510 | -$113,364 | -1.76% | |
| Alyeska Investment Group, L.P. | 0.01% | 81,671 | $4,410,234 | $4,332,647 | -$77,587 | -1.76% | |
| Geode Capital Management, Llc | 0.00% | 70,548 | $3,809,975 | $3,742,571 | -$67,404 | -1.77% | |
| Adar1 Capital Management, Llc | 0.17% | 67,717 | $3,656,718 | $3,592,387 | -$64,331 | -1.76% | |
| Cable Car Capital, Lp | 0.07% | 60,000 | $3,240,000 | $3,183,000 | -$57,000 | -1.76% | |
| Citadel Advisors Llc | 0.00% | 51,905 | $2,802,870 | $2,753,560 | -$49,310 | -1.76% | |
| State Street Corp | 0.00% | 50,450 | $2,724,300 | $2,676,373 | -$47,928 | -1.76% | |
| Boothbay Fund Management, Llc | 0.04% | 42,080 | $2,272,320 | $2,232,344 | -$39,976 | -1.76% | |
| Stempoint Capital Lp | 0.39% | 41,388 | $2,234,952 | $2,195,633 | -$39,319 | -1.76% | |
| Eversept Partners, Lp | 0.12% | 40,000 | $2,160,000 | $2,122,000 | -$38,000 | -1.76% | |
| Carlyle Group Inc. | 0.02% | 38,620 | $2,085,493 | $2,048,791 | -$36,702 | -1.76% | |
| Goldman Sachs Group Inc | 0.00% | 32,348 | $1,746,792 | $1,716,061 | -$30,731 | -1.76% | |
| Affinity Asset Advisors, Llc | 0.08% | 30,000 | $1,620,000 | $1,591,500 | -$28,500 | -1.76% | |
| Diadema Partners Lp | 0.57% | 30,000 | $1,620,000 | $1,591,500 | -$28,500 | -1.76% | |
| Stonepine Capital Management, Llc | 1.18% | 28,795 | $1,554,930 | $1,527,575 | -$27,355 | -1.76% | |
| Point72 Asset Management, L.P. | 0.00% | 28,278 | $1,527,012 | $1,500,148 | -$26,864 | -1.76% | |
| Quinn Opportunity Partners Llc | 0.07% | 26,810 | $1,447,740 | $1,422,271 | -$25,470 | -1.76% | |
| Ubs Group Ag | 0.00% | 23,381 | $1,262,574 | $1,240,362 | -$22,212 | -1.76% | |
| Exoduspoint Capital Management, Lp | 0.01% | 22,000 | $1,188,000 | $1,167,100 | -$20,900 | -1.76% | |
| Northern Trust Corp | 0.00% | 21,083 | $1,138,482 | $1,118,453 | -$20,029 | -1.76% | |
| Knott David M Jr | 0.57% | 20,000 | $1,080,000 | $1,061,000 | -$19,000 | -1.76% | |
| Rosalind Advisors, Inc. | 0.41% | 20,000 | $1,080,000 | $1,061,000 | -$19,000 | -1.76% | |
| Ameriprise Financial Inc | 0.00% | 18,834 | $1,017,036 | $999,144 | -$17,892 | -1.76% | |
| Vanguard Portfolio Management Llc | 0.00% | 18,496 | $998,784 | $981,213 | -$17,571 | -1.76% | |
| Vanguard Fiduciary Trust Co | 0.00% | 18,361 | $991,494 | $974,051 | -$17,443 | -1.76% | |
| Balyasny Asset Management L.P. | 0.00% | 12,138 | $655,452 | $643,921 | -$11,531 | -1.76% | |
| Dimensional Fund Advisors Lp | 0.00% | 8,813 | $476,650 | $467,530 | -$9,120 | -1.91% | |
| Persistent Asset Partners Ltd | 0.13% | 7,677 | $414,558 | $407,265 | -$7,293 | -1.76% | |
| State Board Of Administration Of Florida Retirement System | 0.00% | 7,182 | $387,828 | $381,005 | -$6,823 | -1.76% | |
| Bank Of New York Mellon Corp | 0.00% | 6,779 | $366,057 | $359,626 | -$6,431 | -1.76% | |
| Charles Schwab Investment Management Inc | 0.00% | 5,896 | $318,384 | $312,783 | -$5,601 | -1.76% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 4,700 | $253,800 | $249,335 | -$4,465 | -1.76% |
| Morgan Stanley | 0.00% | 4,411 | $238,194 | $234,004 | -$4,190 | -1.76% | |
| Pale Fire Capital Se | 0.01% | 3,818 | $206,172 | $202,545 | -$3,627 | -1.76% | |
| Rhumbline Advisers | 0.00% | 3,519 | $190,026 | $186,683 | -$3,343 | -1.76% | |
| Deutsche Bank Ag\ | 0.00% | 2,652 | $143,208 | $140,689 | -$2,519 | -1.76% | |
| Wells Fargo & Company/Mn | 0.00% | 2,329 | $125,766 | $123,553 | -$2,213 | -1.76% | |
| New York State Common Retirement Fund | 0.00% | 1,900 | $102,600 | $100,795 | -$1,805 | -1.76% | |
| Citigroup Inc | 0.00% | 1,265 | $68,310 | $67,108 | -$1,202 | -1.76% | |
| Mirae Asset Global Etfs Holdings Ltd. | 0.00% | 1,252 | $67,608 | $66,419 | -$1,189 | -1.76% | |
| Jpmorgan Chase & Co | 0.00% | 1,127 | $62,977 | $59,787 | -$3,190 | -5.06% | |
| Lion Point Capital, Lp | 0.26% | 1,000 | $54,000 | $53,050 | -$950 | -1.76% | |
| Police & Firemen'S Retirement System Of New Jersey | 0.00% | 864 | $46,656 | $45,835 | -$821 | -1.76% | |
| Barclays Plc | 0.00% | 674 | $36,396 | $35,756 | -$640 | -1.76% | |
| Bnp Paribas Financial Markets | 0.00% | 453 | $24,462 | $24,032 | -$430 | -1.76% |
Frequently asked questions about SPRB
Who owns the most SPRB stock?
The largest holders of SPRB are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for SPRUCE BIOSCIENCES INC (SPRB).
Is SPRB widely held by superinvestors?
Many widely followed stocks like SPRB appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly SPRB is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.