SPYRE THERAPEUTICS INC (SYRE) Institutional Ownership Changes & 13F Activity
SPYRE THERAPEUTICS INC (SYRE). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Paradigm Biocapital Advisors Lp, Adage Capital Partners Gp, L.L.C., Price T Rowe Associates Inc, Goldman Sachs Group Inc, and Commodore Capital Lp.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | Sell | -8,325 | -7.4% | 104,516 | $9.28M | Q2 2026 | Sep 09, 2026 |
| Parkside Financial Bank & Trust | Buy | +10 | +28.6% | 45 | $4.00K | Q2 2026 | Sep 04, 2026 |
| Allianz Asset Management Gmbh | Buy | +14,100 | — | 14,100 | $1.25M | Q2 2026 | Sep 02, 2026 |
| Citadel Advisors Llc | Sell | -5,035 | -4.7% | 103,100 | $9.15M | Q2 2026 | Sep 02, 2026 |
| California State Teachers Retirement System | Buy | +5,445 | +9.2% | 64,687 | $5.74M | Q2 2026 | Aug 24, 2026 |
| Mercer Global Advisors Inc | Buy | +54 | +0.1% | 71,145 | $6.32M | Q2 2026 | Aug 19, 2026 |
| Fulcrum Asset Management Llp | Buy | +2,114 | — | 2,114 | $190.60K | Q2 2026 | Aug 18, 2026 |
| Seven Fleet Capital Management Lp | Sell | -6,390 | -32.5% | 13,300 | $1.18M | Q2 2026 | Aug 17, 2026 |
| Empowered Funds, Llc | Buy | +2,731 | — | 2,731 | $242.46K | Q2 2026 | Aug 17, 2026 |
| Paradigm Biocapital Advisors Lp | Buy | +1,883,512 | +96.2% | 3,840,778 | $340.98M | Q2 2026 | Aug 14, 2026 |
| Adage Capital Partners Gp, L.L.C. | Buy | +1,722,300 | — | 1,722,300 | $152.91M | Q2 2026 | Aug 14, 2026 |
| Price T Rowe Associates Inc | Buy | +1,362,125 | +85.2% | 2,960,855 | $262.87M | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Buy | +1,208,121 | +447.6% | 1,478,059 | $131.22M | Q2 2026 | Aug 14, 2026 |
| Commodore Capital Lp | Sell | -1,065,594 | -55.7% | 846,786 | $75.18M | Q2 2026 | Aug 14, 2026 |
| Holocene Advisors, Lp | Buy | +1,015,170 | — | 1,015,170 | $90.13M | Q2 2026 | Aug 14, 2026 |
| Venrock Adviser, Llc | Sell | -700,000 | -19.0% | 2,985,448 | $265.05M | Q2 2026 | Aug 14, 2026 |
| Bank Of America Corp | Buy | +549,761 | +44.8% | 1,777,854 | $157.84M | Q2 2026 | Aug 14, 2026 |
| Perceptive Advisors Llc | Buy | +536,271 | +14.2% | 4,319,496 | $383.48M | Q2 2026 | Aug 14, 2026 |
| Ameriprise Financial Inc | Buy | +356,082 | — | 356,082 | $31.61M | Q2 2026 | Aug 14, 2026 |
| Integral Health Asset Management, Llc | Buy | +325,000 | — | 325,000 | $28.85M | Q2 2026 | Aug 14, 2026 |
| Wellington Management Group Llp | Sell | -243,306 | -13.3% | 1,581,505 | $140.41M | Q2 2026 | Aug 14, 2026 |
| Bellevue Group Ag | Buy | +229,931 | — | 229,931 | $20.41M | Q2 2026 | Aug 14, 2026 |
| Cormorant Asset Management, Lp | Buy | +225,000 | — | 225,000 | $19.98M | Q2 2026 | Aug 14, 2026 |
| Eventide Asset Management, Llc | Buy | +201,616 | — | 201,616 | $17.90M | Q2 2026 | Aug 14, 2026 |
| Polar Capital Holdings Plc | Buy | +195,162 | +24.6% | 988,009 | $87.72M | Q2 2026 | Aug 14, 2026 |
| Boothbay Fund Management, Llc | Sell | -186,578 | -96.7% | 6,453 | $572.90K | Q2 2026 | Aug 14, 2026 |
| Orbimed Advisors Llc | Buy | +186,145 | — | 186,145 | $16.53M | Q2 2026 | Aug 14, 2026 |
| Frontier Capital Management Co Llc | Buy | +182,931 | — | 182,931 | $16.24M | Q2 2026 | Aug 14, 2026 |
| Squarepoint Ops Llc | Buy | +139,605 | — | 139,605 | $12.39M | Q2 2026 | Aug 14, 2026 |
| Seven Grand Managers, Llc | Buy | +125,000 | +125.0% | 225,000 | $19.98M | Q2 2026 | Aug 14, 2026 |
Frequently asked questions about SYRE activity
Which institutional owners are buying SYRE?
Institutional owners buying SYRE include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in SYRE activity?
"Buy" means an investor increased their reported position in SYRE compared to the prior reporting period. This reflects growing exposure to SPYRE THERAPEUTICS INC (SYRE) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in SYRE increasing?
Institutional interest in SYRE can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
Related SYRE Institutional Insights
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- Healthcare Sector Institutional Ownership
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- Institutional Portfolio Overlap & Shared Holdings
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- SYRE Insider Trading & SEC Form 4 Activity
- SYRE Articles
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