SPYRE THERAPEUTICS INC (SYRE) Institutional Ownership Changes & 13F Activity

SPYRE THERAPEUTICS INC (SYRE). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Paradigm Biocapital Advisors Lp, Adage Capital Partners Gp, L.L.C., Price T Rowe Associates Inc, Goldman Sachs Group Inc, and Commodore Capital Lp.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Manufacturers Life Insurance Company, TheSell-8,325-7.4%104,516$9.28MQ2 2026Sep 09, 2026
Parkside Financial Bank & TrustBuy+10+28.6%45$4.00KQ2 2026Sep 04, 2026
Allianz Asset Management GmbhBuy+14,10014,100$1.25MQ2 2026Sep 02, 2026
Citadel Advisors LlcSell-5,035-4.7%103,100$9.15MQ2 2026Sep 02, 2026
California State Teachers Retirement SystemBuy+5,445+9.2%64,687$5.74MQ2 2026Aug 24, 2026
Mercer Global Advisors IncBuy+54+0.1%71,145$6.32MQ2 2026Aug 19, 2026
Fulcrum Asset Management LlpBuy+2,1142,114$190.60KQ2 2026Aug 18, 2026
Seven Fleet Capital Management LpSell-6,390-32.5%13,300$1.18MQ2 2026Aug 17, 2026
Empowered Funds, LlcBuy+2,7312,731$242.46KQ2 2026Aug 17, 2026
Paradigm Biocapital Advisors LpBuy+1,883,512+96.2%3,840,778$340.98MQ2 2026Aug 14, 2026
Adage Capital Partners Gp, L.L.C.Buy+1,722,3001,722,300$152.91MQ2 2026Aug 14, 2026
Price T Rowe Associates IncBuy+1,362,125+85.2%2,960,855$262.87MQ2 2026Aug 14, 2026
Goldman Sachs Group IncBuy+1,208,121+447.6%1,478,059$131.22MQ2 2026Aug 14, 2026
Commodore Capital LpSell-1,065,594-55.7%846,786$75.18MQ2 2026Aug 14, 2026
Holocene Advisors, LpBuy+1,015,1701,015,170$90.13MQ2 2026Aug 14, 2026
Venrock Adviser, LlcSell-700,000-19.0%2,985,448$265.05MQ2 2026Aug 14, 2026
Bank Of America CorpBuy+549,761+44.8%1,777,854$157.84MQ2 2026Aug 14, 2026
Perceptive Advisors LlcBuy+536,271+14.2%4,319,496$383.48MQ2 2026Aug 14, 2026
Ameriprise Financial IncBuy+356,082356,082$31.61MQ2 2026Aug 14, 2026
Integral Health Asset Management, LlcBuy+325,000325,000$28.85MQ2 2026Aug 14, 2026
Wellington Management Group LlpSell-243,306-13.3%1,581,505$140.41MQ2 2026Aug 14, 2026
Bellevue Group AgBuy+229,931229,931$20.41MQ2 2026Aug 14, 2026
Cormorant Asset Management, LpBuy+225,000225,000$19.98MQ2 2026Aug 14, 2026
Eventide Asset Management, LlcBuy+201,616201,616$17.90MQ2 2026Aug 14, 2026
Polar Capital Holdings PlcBuy+195,162+24.6%988,009$87.72MQ2 2026Aug 14, 2026
Boothbay Fund Management, LlcSell-186,578-96.7%6,453$572.90KQ2 2026Aug 14, 2026
Orbimed Advisors LlcBuy+186,145186,145$16.53MQ2 2026Aug 14, 2026
Frontier Capital Management Co LlcBuy+182,931182,931$16.24MQ2 2026Aug 14, 2026
Squarepoint Ops LlcBuy+139,605139,605$12.39MQ2 2026Aug 14, 2026
Seven Grand Managers, LlcBuy+125,000+125.0%225,000$19.98MQ2 2026Aug 14, 2026
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Frequently asked questions about SYRE activity

  • Which institutional owners are buying SYRE?

    Institutional owners buying SYRE include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SYRE activity?

    "Buy" means an investor increased their reported position in SYRE compared to the prior reporting period. This reflects growing exposure to SPYRE THERAPEUTICS INC (SYRE) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SYRE increasing?

    Institutional interest in SYRE can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.