ORCHESTRA BIOMED HOLDINGS IN (OBIO) Top Institutional Shareholders
ORCHESTRA BIOMED HOLDINGS IN (OBIO) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $97.96M in OBIO holdings during the latest filing period.
Rtw Investments, Lp is currently the largest disclosed institutional shareholder of OBIO tracked by InsiderSet, reporting ownership valued at approximately $35.30M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $32.14M, representing an estimated loss of -8.94% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 87% of the total disclosed OBIO value among the investors covered in this analysis. Major shareholders include Rtw Investments, Lp, Perceptive Advisors Llc, Vanguard Capital Management Llc, and several other long-term asset managers with concentrated positions in ORCHESTRA BIOMED HOLDINGS IN (OBIO).
This page ranks the largest institutional OBIO shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
64
Total Reported Value
$97.96M
Largest Holder
Rtw Investments, Lp
Largest Position
$35.30M
Insider Transactions (90d)
0
Latest Filing Quarter
Q1 2026
New Institutional Positions
81
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Rtw Investments, Lp | 0.35% | 8,306,063 | $35,300,768 | $32,144,464 | -$3,156,304 | -8.94% | |
| Perceptive Advisors Llc | 0.42% | 5,037,906 | $21,411,101 | $19,496,696 | -$1,914,405 | -8.94% | |
| Vanguard Capital Management Llc | 0.00% | 2,204,319 | $9,368,356 | $8,530,715 | -$837,641 | -8.94% | |
| Alyeska Investment Group, L.P. | 0.01% | 1,000,000 | $4,250,000 | $3,870,000 | -$380,000 | -8.94% | |
| Propel Bio Management, Llc | 2.41% | 896,701 | $3,830,724 | $3,470,233 | -$360,491 | -9.41% | |
| Millennium Management Llc | 0.00% | 702,543 | $2,985,808 | $2,718,841 | -$266,967 | -8.94% | |
| Blackrock, Inc. | 0.00% | 635,714 | $2,701,784 | $2,460,213 | -$241,571 | -8.94% | |
| Geode Capital Management, Llc | 0.00% | 485,492 | $2,064,440 | $1,878,854 | -$185,586 | -8.99% | |
| Affinity Asset Advisors, Llc | 0.10% | 402,550 | $1,710,838 | $1,557,869 | -$152,970 | -8.94% | |
| Charles Schwab Investment Management Inc | 0.00% | 265,499 | $1,128,371 | $1,027,481 | -$100,890 | -8.94% | |
| Knott David M Jr | 0.64% | 253,651 | $1,078,017 | $981,629 | -$96,388 | -8.94% | |
| Vanguard Fiduciary Trust Co | 0.00% | 235,214 | $999,660 | $910,278 | -$89,382 | -8.94% | |
| Simplify Asset Management Inc. | 0.01% | 219,387 | $932,395 | $849,028 | -$83,367 | -8.94% | |
| Marshall Wace, Llp | 0.00% | 188,484 | $801,059 | $729,433 | -$71,626 | -8.94% | |
| 683 Capital Management, Llc | 0.07% | 185,000 | $786,250 | $715,950 | -$70,300 | -8.94% | |
| State Street Corp | 0.00% | 169,410 | $719,993 | $655,617 | -$64,376 | -8.94% | |
| Goldman Sachs Group Inc | 0.00% | 155,242 | $659,779 | $600,787 | -$58,992 | -8.94% | |
| Dafna Capital Management Llc | 0.12% | 126,841 | $539,074 | $490,875 | -$48,199 | -8.94% | |
| Northern Trust Corp | 0.00% | 118,274 | $502,665 | $457,720 | -$44,945 | -8.94% | |
| Qube Research & Technologies Ltd | 0.00% | 108,953 | $463,050 | $421,648 | -$41,402 | -8.94% | |
| Ifp Advisors, Inc | 0.01% | 98,887 | $420,270 | $382,693 | -$37,577 | -8.94% | |
| Susquehanna International Group, Llp | 0.00% | 97,521 | $414,464 | $377,406 | -$37,058 | -8.94% | |
| Point72 Asset Management, L.P. | 0.00% | 87,888 | $373,524 | $340,127 | -$33,397 | -8.94% | |
| Citadel Advisors Llc | 0.00% | 79,185 | $336,536 | $306,446 | -$30,090 | -8.94% | |
| Hudson Bay Capital Management Lp | 0.00% | 71,134 | $302,320 | $275,289 | -$27,031 | -8.94% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 70,900 | $301,325 | $274,383 | -$26,942 | -8.94% |
| Bridgeway Capital Management, Llc | 0.01% | 70,600 | $300,050 | $273,222 | -$26,828 | -8.94% | |
| Two Sigma Investments, Lp | 0.00% | 60,107 | $255,455 | $232,614 | -$22,841 | -8.94% | |
| Barclays Plc | 0.00% | 59,342 | $252,204 | $229,654 | -$22,550 | -8.94% | |
| Jane Street Group, Llc | 0.00% | 55,680 | $236,640 | $215,482 | -$21,158 | -8.94% | |
| Daytona Street Capital Llc | 0.18% | 52,600 | $235,443 | $203,562 | -$31,881 | -13.54% | |
| Bank Of America Corp | 0.00% | 52,761 | $224,234 | $204,185 | -$20,049 | -8.94% | |
| Holos Integrated Wealth Llc | 0.11% | 51,595 | $219,795 | $199,673 | -$20,122 | -9.16% | |
| Ubs Group Ag | 0.00% | 50,310 | $213,818 | $194,700 | -$19,118 | -8.94% | |
| Brevan Howard Capital Management Lp | 0.00% | 36,769 | $156,268 | $142,296 | -$13,972 | -8.94% | |
| Morgan Stanley | 0.00% | 35,639 | $151,466 | $137,923 | -$13,543 | -8.94% | |
| Meramec Financial Planners, Llc | 0.05% | 30,000 | $130,500 | $116,100 | -$14,400 | -11.03% | |
| Catalyst Funds Management Pty Ltd | 0.02% | 27,644 | $117,487 | $106,982 | -$10,505 | -8.94% | |
| Citigroup Inc | 0.00% | 25,529 | $108,498 | $98,797 | -$9,701 | -8.94% | |
| Cannon Global Investment Management, Llc | 0.23% | 22,607 | $96,080 | $87,489 | -$8,591 | -8.94% | |
| Rice Hall James & Associates, Llc | 0.00% | 19,001 | $80,754 | $73,534 | -$7,220 | -8.94% | |
| Diametric Capital, Lp | 0.02% | 18,919 | $80,405 | $73,217 | -$7,188 | -8.94% | |
| Hightower Advisors, Llc | 0.00% | 18,275 | $77,669 | $70,724 | -$6,945 | -8.94% | |
| Fmr Llc | 0.00% | 18,076 | $76,824 | $69,954 | -$6,870 | -8.94% | |
| Omers Administration Corp | 0.00% | 16,200 | $68,850 | $62,694 | -$6,156 | -8.94% | |
| Vanguard Global Advisers, Llc | 0.00% | 13,948 | $59,279 | $53,979 | -$5,300 | -8.94% | |
| Able Financial Group, Llc | 0.01% | 13,402 | $56,959 | $51,866 | -$5,093 | -8.94% | |
| Frec Markets, Inc. | 0.01% | 13,048 | $55,454 | $50,496 | -$4,958 | -8.94% | |
| Prelude Capital Management, Llc | 0.00% | 12,389 | $52,653 | $47,945 | -$4,708 | -8.94% | |
| Canada Pension Plan Investment Board | 0.00% | 11,300 | $48,025 | $43,731 | -$4,294 | -8.94% |
Frequently asked questions about OBIO
Who owns the most OBIO stock?
The largest holders of OBIO are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for ORCHESTRA BIOMED HOLDINGS IN (OBIO).
Is OBIO widely held by superinvestors?
Many widely followed stocks like OBIO appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly OBIO is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.