EDGEWISE THERAPEUTICS INC (EWTX) Institutional Shareholders
EDGEWISE THERAPEUTICS INC (EWTX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $4.73B in EWTX holdings during the latest filing period.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of EWTX tracked by InsiderSet, reporting ownership valued at approximately $630.52M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $685.45M, representing an estimated gain of +8.71% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 59% of the total disclosed EWTX value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Paradigm Biocapital Advisors Lp, Ra Capital Management, L.P., and several other long-term asset managers with concentrated positions in EDGEWISE THERAPEUTICS INC (EWTX).
This page ranks the largest institutional EWTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
221
Total Reported Value
$4.73B
Largest Holder
Orbimed Advisors Llc
Largest Position
$630.52M
Insider Transactions (90d)
32
Latest Filing Quarter
Q2 2026
New Institutional Positions
67
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 11.94% | 15,518,492 | $630,516,330 | $685,451,792 | +$54,935,462 | +8.71% | |
| Paradigm Biocapital Advisors Lp | 7.77% | 10,215,455 | $415,053,937 | $451,216,647 | +$36,162,710 | +8.71% | |
| Ra Capital Management, L.P. | 2.96% | 8,392,730 | $340,996,620 | $370,706,884 | +$29,710,264 | +8.71% | |
| Blackrock, Inc. | 0.00% | 6,606,336 | $268,415,431 | $291,801,861 | +$23,386,430 | +8.71% | |
| Fmr Llc | 0.01% | 5,489,135 | $223,023,556 | $242,455,093 | +$19,431,537 | +8.71% | |
| Novo Holdings A/S | 12.62% | 5,350,000 | $217,370,500 | $236,309,500 | +$18,939,000 | +8.71% | |
| Driehaus Capital Management Llc | 1.11% | 4,728,623 | $192,123,952 | $208,863,278 | +$16,739,326 | +8.71% | |
| Janus Henderson Group Plc | 0.09% | 5,915,556 | $186,289,082 | $261,290,109 | +$75,001,027 | +40.26% | |
| Perceptive Advisors Llc | 2.76% | 4,373,974 | $177,714,564 | $193,198,432 | +$15,483,868 | +8.71% | |
| Vanguard Capital Management Llc | 0.00% | 3,860,670 | $156,859,022 | $170,525,794 | +$13,666,772 | +8.71% | |
| Baker Bros. Advisors Lp | 0.75% | 3,701,719 | $150,400,843 | $163,504,928 | +$13,104,085 | +8.71% | |
| Siren, L.L.C. | 2.63% | 3,184,629 | $129,391,476 | $140,665,063 | +$11,273,587 | +8.71% | |
| Cormorant Asset Management, Lp | 5.23% | 2,510,000 | $101,981,300 | $110,866,700 | +$8,885,400 | +8.71% | |
| Geode Capital Management, Llc | 0.00% | 2,174,051 | $88,348,054 | $96,027,833 | +$7,679,779 | +8.69% | |
| Integral Health Asset Management, Llc | 3.33% | 2,000,000 | $81,260,000 | $88,340,000 | +$7,080,000 | +8.71% | |
| Braidwell Lp | 3.00% | 1,996,965 | $81,136,688 | $88,205,944 | +$7,069,256 | +8.71% | |
| Morgan Stanley | 0.00% | 1,948,597 | $79,171,495 | $86,069,529 | +$6,898,034 | +8.71% | |
| State Street Corp | 0.00% | 1,827,927 | $74,268,674 | $80,739,536 | +$6,470,862 | +8.71% | |
| Alliancebernstein L.P. | 0.02% | 2,119,024 | $66,749,256 | $93,597,290 | +$26,848,034 | +40.22% | |
| Mpm Bioimpact Llc | 4.02% | 1,620,780 | $65,852,291 | $71,589,853 | +$5,737,562 | +8.71% | |
| Bank Of America Corp | 0.00% | 1,558,260 | $63,312,105 | $68,828,344 | +$5,516,239 | +8.71% | |
| Qube Research & Technologies Ltd | 0.06% | 1,252,507 | $50,889,359 | $55,323,234 | +$4,433,875 | +8.71% | |
| Dimensional Fund Advisors Lp | 0.01% | 1,139,726 | $46,309,097 | $50,341,697 | +$4,032,600 | +8.71% | |
| American Century Companies Inc | 0.02% | 1,127,078 | $45,793,233 | $49,783,035 | +$3,989,802 | +8.71% | |
| First Light Asset Management, Llc | 2.70% | 1,095,171 | $44,496,798 | $48,373,703 | +$3,876,905 | +8.71% | |
| Victory Capital Management Inc | 0.02% | 902,870 | $36,683,608 | $39,879,768 | +$3,196,160 | +8.71% | |
| Vanguard Portfolio Management Llc | 0.00% | 786,456 | $31,953,707 | $34,737,762 | +$2,784,055 | +8.71% | |
| Northern Trust Corp | 0.00% | 671,270 | $27,273,701 | $29,649,996 | +$2,376,295 | +8.71% | |
| Aberdeen Group Plc | 0.04% | 647,926 | $26,325,233 | $28,618,891 | +$2,293,658 | +8.71% | |
| Charles Schwab Investment Management Inc | 0.00% | 620,532 | $25,212,215 | $27,408,898 | +$2,196,683 | +8.71% | |
| Sixth Street Partners Management Company, L.P. | 0.00% | 620,532 | $25,212,215 | $27,408,898 | +$2,196,683 | +8.71% | |
| Tyro Capital Management Llc | 5.59% | 612,965 | $24,904,768 | $27,074,664 | +$2,169,896 | +8.71% | |
| Goldman Sachs Group Inc | 0.00% | 599,469 | $24,356,425 | $26,478,546 | +$2,122,121 | +8.71% | |
| Parkman Healthcare Partners Llc | 2.41% | 577,036 | $23,444,973 | $25,487,680 | +$2,042,707 | +8.71% | |
| Artisan Partners Limited Partnership | 0.04% | 574,925 | $23,359,203 | $25,394,437 | +$2,035,234 | +8.71% | |
| Vanguard Fiduciary Trust Co | 0.00% | 548,285 | $22,276,820 | $24,217,748 | +$1,940,928 | +8.71% | |
| Norges Bank | 0.00% | 510,140 | $20,726,988 | $22,532,884 | +$1,805,896 | +8.71% | |
| Opaleye Management Inc. | 1.84% | 500,000 | $20,315,000 | $22,085,000 | +$1,770,000 | +8.71% | |
| Citadel Advisors Llc | 0.01% | 469,707 | $19,084,196 | $20,746,958 | +$1,662,762 | +8.71% | |
| Adage Capital Partners Gp, L.L.C. | 0.03% | 462,000 | $18,771,060 | $20,406,540 | +$1,635,480 | +8.71% | |
| Soleus Capital Management, L.P. | 0.63% | 450,889 | $18,319,620 | $19,915,767 | +$1,596,147 | +8.71% | |
| Nuveen, Llc | 0.00% | 414,706 | $16,849,506 | $18,317,564 | +$1,468,058 | +8.71% | |
| Sofinnova Investments, Inc. | 0.83% | 380,923 | $15,476,901 | $16,825,369 | +$1,348,468 | +8.71% | |
| Healthcare Of Ontario Pension Plan Trust Fund | 0.02% | 334,014 | $13,570,989 | $14,753,398 | +$1,182,409 | +8.71% | |
| Squadron Capital Management Llc | 4.03% | 290,000 | $11,782,700 | $12,809,300 | +$1,026,600 | +8.71% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.02% | 283,333 | $11,511,820 | $12,514,819 | +$1,002,999 | +8.71% | |
| Diadema Partners Lp | 3.91% | 272,214 | $11,060,055 | $12,023,692 | +$963,637 | +8.71% | |
| Prudential Financial Inc | 0.01% | 260,725 | $10,593,257 | $11,516,223 | +$922,966 | +8.71% | |
| Kennedy Capital Management Llc | 0.18% | 256,608 | $10,425,983 | $11,334,375 | +$908,392 | +8.71% | |
| Schonfeld Strategic Advisors Llc | 0.05% | 255,202 | $10,368,855 | $11,272,272 | +$903,417 | +8.71% |
Frequently asked questions about EWTX
Who owns the most EWTX stock?
The largest holders of EWTX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for EDGEWISE THERAPEUTICS INC (EWTX).
Is EWTX widely held by superinvestors?
Many widely followed stocks like EWTX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly EWTX is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.