VERTEX PHARMACEUTICALS INC (VRTX) Stock Institutional Trading Activity


VERTEX PHARMACEUTICALS INC (VRTX) position changes reported by tracked institutional filers across multiple SEC 13F reporting periods. Based on recent SEC 13F filings (Q4 2025), investors with some of the largest reported share count changes include Renaissance Technologies LLC, Tweedy, Browne Co All Funds (US), Parnassus Endeavor Fund, ARK Invest, and Torray Fund. Explore insights into buying and selling patterns, position changes, and investment conviction levels to understand institutional trading behavior and market dynamics.

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Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q4 2025Tweedy, Browne Co All Funds (US)Buy8339,148$17,748,137
Q4 2025Renaissance Technologies LLCSell-230,840505,048$228,968,561
Q3 2025Torray FundSell-62416,255$6,366,108
Q3 2025Tweedy, Browne Co All Funds (US)Buy1,81239,065$15,299,417
Q3 2025ARK InvestBuy1,60225,665$10,051,390
Q3 2025Sequoia Financial AdvisorsSell-39313,980$5,475,119
Q3 2025Renaissance Technologies LLCSell-269,000735,888$288,203,176
Q3 2025Parnassus Endeavor FundSell-63,0071,648,433$645,592,300
Q2 2025Torray FundBuy1,15816,879$7,514,531
Q2 2025Tweedy, Browne Co All Funds (US)Sell-1,06337,253$16,585,036
Q2 2025ARK InvestSell-2,28124,063$10,712,990
Q2 2025Sequoia Financial AdvisorsBuy44214,373$6,398,641
Q2 2025Renaissance Technologies LLCSell-166,6831,004,888$447,376,138
Q2 2025Parnassus Endeavor FundSell-61,2781,711,440$761,933,088
Q1 2025Torray FundSell-28715,721$7,621,855
Q1 2025Tweedy, Browne Co All Funds (US)Sell-2,31538,316$18,576,363
Q1 2025ARK InvestBuy99426,344$12,772,279
Q1 2025Sequoia Financial AdvisorsBuy1,04113,931$6,753,866
Q1 2025Renaissance Technologies LLCSell-225,6381,171,571$568,001,052
Q1 2025Parnassus Endeavor FundSell-43,2321,772,718$859,449,141
Q4 2024Torray FundBuy25716,008$6,446,422
Q4 2024Tweedy, Browne Co All Funds (US)Sell-12,96940,631$16,362,104
Q4 2024ARK InvestSell-25,74925,350$10,208,544
Q4 2024Sequoia Financial AdvisorsBuy60212,890$5,190,979
Q4 2024Renaissance Technologies LLCSell-234,2841,397,209$562,656,064
Q4 2024Parnassus Endeavor FundBuy1,815,2121,815,950$731,283,065
Q3 2024Torray FundBuy1,81315,751$7,325,475
Q3 2024Tweedy, Browne Co All Funds (US)Sell-74653,600$24,928,288
Q3 2024ARK InvestSell-24,36551,099$23,764,968
Q3 2024Sequoia Financial AdvisorsBuy1,14712,288$5,715,106

Frequently asked questions about VRTX activity

  • Which institutional owners are buying VRTX?

    Institutional owners buying VRTX include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in VRTX activity?

    "Buy" means an investor increased their reported position in VRTX compared to the prior reporting period. This reflects growing exposure to VERTEX PHARMACEUTICALS INC (VRTX) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in VRTX increasing?

    Institutional interest in VRTX can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.